Recombinant Human H (+)/Cl (-) exchange transporter 3 (CLCN3)

1. Unique oligomerization properties of ClC-4 permit regulated targeting of ClC-4 to various endosomal compartment systems via expression of different ClC-3 splice variants. PMID:28972156
2. we demonstrated that ClC-3 can arrest the cell cycle at the G1 phase to inhibit cell proliferation, suggesting that ClC-3 has the potential to be a novel target for hepatocellular carcinoma (HCC) therapy and potentially improve the prognosis of HCC patients PMID:29749557
3. CLC-3 may get involved in proliferation, invasion, and migration of ovarian cancer cells and thus may be a useful therapeutic target. PMID:29787012
4. ClC-3 is a potential target of 17beta-estradiol and is modulated by the ERalpha in breast cancer cells. PMID:28419445
5. Study provided novel and compelling evidence for the functional role of the unique CLC-3, which are significantly upregulated during ischemia, in the protection of the heart under stress PMID:27064645
6. ClC-3 promotes endometriotic cell migration and invasion. PMID:26965430
7. these results demonstrated that ClC-3 is involved in the proliferation and migration of osteosarcoma cell PMID:25973047
8. Data indicate that cytoplasmic chloride channel-3 (ClC-3) plays an active and key role in tumor metastasis and may be a valuable prognostic biomarker and a therapeutic target to prevent tumor spread. PMID:25537517
9. CLC3 is required in the activation and migration of human blood eosinophils. PMID:25514499
10. Authors summarize the function of CLC-3 in cancer and discuss the mechanisms by which CLC-3 contributes to proliferation, apoptosis and drug resistance in cancer cells. [Review] PMID:25421907
11. swelling-activated Cl currents and CLC-3 play a role in pulmonary artery smooth muscle cell proliferation, but CLC-3 channels do not underlie swelling in these cells PMID:24284495
12. ClC-3 deficiency inhibited Ang II-induced EPC apoptosis via suppressing ROS generation derived from NADPH oxidase. PMID:23873092
13. Suggest that ClC-3 suppression causes the inhibition of Akt and autophagy, which can enhance the therapeutic benefit of cisplatin in U251 cells. PMID:23408563
14. K(Ca)3.1 and ClC-3 are expressed in tissue samples obtained from patients diagnosed with grade IV gliomas. Both K(Ca)3.1 and ClC-3 colocalize to the invading processes of glioma cells PMID:23345219
15. Data indicate in umbilical vein endothelial cells transfected with ClC-3 siRNA showed activation of NF-kappaB. PMID:23006728
16. results reveal a cell cycle-dependent change of the subcellular distribution of ClC-3 and strongly suggest that ClC-3 has nucleocytoplasmic shuttling dynamics that may play key regulatory roles during different stages of the cell cycle in tumor cells. PMID:22371056
17. ClC-3 is a candidate of the channel proteins that mediate or regulate the acid-activated chloride current in nasopharyngeal carcinoma cells. PMID:22496242
18. ClC-3 protein may be considered as a potential tumor marker and therapeutic target for human nasopharyngeal carcinoma. PMID:22108225
19. ClC-3 may be a main component of background chloride channels which can be activated under isotonic conditions by autocrine/paracrine ATP through purinergic receptor pathways; the background current is involved in maintenance of basal cell volume. PMID:21792908
20. ClC-3 is involved in the activation of volume-activated chloride currents but not of stretch-activated chloride currents in hepatocellular carcinoma cells. PMID:20945353
21. High ClC-3 is associated with extensive migration and invasion in glioma. PMID:21115901
22. ClC-3 is an important molecular component underlying VSOACs and the RVD process in HeLa cells PMID:12183454
23. results show that the ClC-3B PDZ-binding isoform resides in the Golgi where it co-localizes with a small amount of CFTR (cystic fibrosis transmembrane conductance regulator) PMID:12471024
24. results suggest a fundamental role of endogenous ClC-3 in the swelling-activated Cl- channels function and cell volume regulation in human gastric epithelial cells PMID:12842831
25. ClC-3 and ZnT3 reside in a common vesicle population where they functionally interact to determine vesicle luminal composition. PMID:15073168
26. volume-regulated ClC-3 Cl(-) channels play important role in the regulation of [Cl(-)](i) and cell proliferation of vascular smooth muscle cells PMID:15596438
27. Clcn3 was considered the most likely candidate of Cl- channel involved in volume regulation of human sperm. PMID:16033995
28. ClC-3 is required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration PMID:16522634
29. This study demonstrates that superoxide flux across the endothelial cell plasma membrane occurs through chloride channel-3 channels and induces intracellular calcium release, which activates mitochondrial superoxide generation. PMID:17360969
30. The relative density of CLC-3 mRNA was 0.22+/-0.09 and 0.12+/-0.05 in HNECs treated with 3 and 0.9% saline, respectively. PMID:17869465
31. CLC-3 is upregulated in ethmoid mucosa and may affect the development of chronic rhinosinusitis without nasal polyps. PMID:17882904
32. inhibition of the NADPH oxidase or ClC-3 in otherwise unstimulated cells elicited a phenotype similar to that seen after endotoxin priming, suggesting that basal oxidant production helps to maintain cellular quiescence. PMID:17908687
33. oxidation induces surface expression of ClC-3 and activation of a ClC-3-dependent anion permeability in K562 cells PMID:17976378
34. ClC-3 overexpression induced a pH-sensitive conductance in HEK293T cells that is biophysically similar to ClC-4 and ClC-5. PMID:17977943
35. These data confirm that ClC-3 is important in VRAC function and cell volume regulation, is associated with the I(Cl,LPA) current activity, and participates in the fibroblast-to-myofibroblast transition. PMID:18077605
36. An essential role of sClC-3 in native volume-sensitive outwardly rectifying anion channels function in mouse atrial myocytes. PMID:18986326

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HGNC: 2021

UNIGENE: Hs.481186

KEGG: hsa:1182

STRING: 9606.ENSP00000261514

OMIM: 600580